Recently, Professor Yuan Lingqing, Chief Physician and Distinguished Researcher of National Clinical Research Center for Metabolic Diseases, and the Department of Metabolic Endocrinology from Second Xiangya Hospital of Central South University, and Professor Liu Youshuo from the National Clinical Research Center for Geriatric Disorders/Department of Geriatric Medicine of Central South University jointly published a paper entitled “Melatonin alleviates vascular calcification and senescence through exosomal miR-204/miR-211 cluster in a paracrine manner” in the top international endocrine journal Journal of Pineal Research. Professor Yuan Lingqing is the corresponding author, the Second Xiangya Hospital of Central South University is the units for the first author and the sole corresponding author, Professor Liu Youshuo is the co-corresponding author, and PhD students Xu Feng and Zhong Jiayu are the co-first authors.
Aging of population is an important issue in the world. As we age, cardiovascular events increase significantly, and the incidence of arterial calcification increases significantly. Melatonin is an amine hormone produced by the pineal gland, which has certain effects on sleep, diet, mental state and stress. Melatonin secretion gradually decreases with age. Many studies have found that melatonin plays an important role in hypertension and atherosclerosis. Exosomes are an important new carrier to mediate the crosstalk between cells and between tissues. The research of Yuan Lingqing’s team found that melatonin promotes vascular smooth muscle cells (VSMCs) to secret miR-204/miR-211-rich exosomes, which are taken up by VSMCs in vivo and in vitro to inhibit the transdifferentiation and senescence of VSMCs, and then inhibit the occurrence and development of arterial calcification. Paracrine between cells is a major problem in the scientific community, and the paracrine mediator is a difficulty that hinders the study of paracrine. Yuan Lingqing’s team revealed the paracrine mechanism between cells and between tissues through exosomes.
This study was supported by the National Natural Science Foundation of China and the Graduate Innovation Project of Central South University.
(The mechanism diagram about attenuating vascular calcification and senescence by melatonin in a paracrine manner)
Source: Second Xiangya Hospital